Host Polyunsaturated Fatty Acids Potentiate Aminoglycoside Killing of Staphylococcus aureus.

ABSTRACT: Aminoglycoside antibiotics rely on the proton motive force to enter the bacterial cell, and facultative anaerobes like Staphylococcus aureus can shift energy generation from respiration to fermentation, becoming tolerant of aminoglycosides. Following this metabolic shift, high concentrations of aminoglycosides are required to eradicate S. aureus infections, which endangers the host due to the toxicity of aminoglycosides. Membrane-disrupting molecules prevent aminoglycoside tolerance in S. aureus by facilitating passive entry of the drug through the membrane. Polyunsaturated fatty acids (PUFAs) increase membrane permeability when incorporated into S. aureus. Here, we report that the abundant host-derived PUFA arachidonic acid increases the susceptibility of S. aureus to aminoglycosides, dec

SUBMITTER: Beavers WN 

PROVIDER: S-EPMC9045252 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature