An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains.

ABSTRACT: Bacterial genes coding for antibiotic resistance represent a major issue in the fight against bacterial pathogens. Among those, genes encoding beta-lactamases target penicillin and related compounds such as carbapenems, which are critical for human health. Beta-lactamases are classified into classes A, B, C, and D, based on their amino acid sequence. Class D enzymes are also known as OXA beta-lactamases, due to the ability of the first enzymes described in this class to hydrolyze oxacillin. While hundreds of class D beta-lactamases with different activity profiles have been isolated from clinical strains, their nomenclature remains very uninformative. In this work, we have carried out a comprehensive survey of a reference database of 80,490 genomes and identified 24,916 OXA-domain containi

SUBMITTER: Lupo V 

PROVIDER: S-EPMC9045261 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature