Contributions of Human-Associated Archaeal Metabolites to Tumor Microenvironment and Carcinogenesis.

ABSTRACT: There is increasing awareness that archaea are interrelated with human diseases (including cancer). Archaea utilize unique metabolic pathways to produce a variety of metabolites that serve as a direct link to host-microbe interactions. However, knowledge on the diversity of human-associated archaea is still extremely limited, and less is known about the pathological effects of their metabolites to the tumor microenvironment and carcinogenesis. In the present study, we performed a large-scale analysis of archaea and their cancer-related metabolites across different body sites using >44,000 contigs with length >1,000 bp. Taxonomy annotation revealed that the occurrence and diversity of archaea are higher in two body sites, the gut and the oral cavity. Unlike other human-associated microbes,

SUBMITTER: Cai M 

PROVIDER: S-EPMC9045267 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature