Conserved Pattern and Potential Role of Recurrent Deletions in SARS-CoV-2 Evolution.

ABSTRACT: SARS-CoV-2 continues adapting to human hosts during the current worldwide pandemic since 2019. This virus evolves through multiple means, such as single nucleotide mutations and structural variations, which has brought great difficulty to disease prevention and control of COVID-19. Structural variation, including multiple nucleotide changes like insertions and deletions, has a greater impact relative to single nucleotide mutation on both genome structures and protein functions. In this study, we found that deletion occurred frequently in not only SARS-CoV-2 but also in other SARS-related coronaviruses. These deletions showed obvious location bias and formed 45 recurrent deletion regions in the viral genome. Some of these deletions showed proliferation advantages, including four high-freque

SUBMITTER: Weng S 

PROVIDER: S-EPMC9045279 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature