Distinct Roles of Honeybee Gut Bacteria on Host Metabolism and Neurological Processes.

ABSTRACT: The honeybee possesses a limited number of bacterial phylotypes that play essential roles in host metabolism, hormonal signaling, and feeding behavior. However, the contribution of individual gut members in shaping honeybee brain profiles remains unclear. By generating gnotobiotic bees which were mono-colonized by a single gut bacterium, we revealed that different species regulated specific modules of metabolites in the hemolymph. Circulating metabolites involved in carbohydrate and glycerophospholipid metabolism pathways were mostly regulated by Gilliamella, while Lactobacillus Firm4 and Firm5 mainly altered amino acid metabolism pathways. We then analyzed the brain transcriptomes of bees mono-colonized with these three bacteria. These showed distinctive gene expression prof

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC9045319 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature