Association of nitric oxide synthase 1 adaptor protein gene polymorphisms with schizophrenia in a Chinese Han population.

ABSTRACT:

Introduction

Previous studies have analyzed the association between nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphisms and schizophrenia; however, the results were inconsistent and there was a lack of evidence in a larger sample of Chinese Han population.

Subjects and methods

We decided to determine the association between four NOS1AP single-nucleotide polymorphisms (i.e., rs1858232A/G, rs4531275C/T, rs4657178C/T, and rs6704393C/T) and schizophrenia in northern Chinese Han population (350 patients and 522 controls) using restriction fragment length polymorphism.

Results

Between schizophrenia group and healthy group, the genotype and allele frequencies for rs1858232A/G differed significantly (χ ² = 6.256, 4.145; P = 0.

SUBMITTER: Yang X 

PROVIDER: S-EPMC9045341 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature