Deep learning identifies brain structures that predict cognition and explain heterogeneity in cognitive aging.

ABSTRACT: Specific brain structures (gray matter regions and white matter tracts) play a dominant role in determining cognitive decline and explain the heterogeneity in cognitive aging. Identification of these structures is crucial for screening of older adults at risk of cognitive decline. Using deep learning models augmented with a model-interpretation technique on data from 1432 Mayo Clinic Study of Aging participants, we identified a subset of brain structures that were most predictive of individualized cognitive trajectories and indicative of cognitively resilient vs. vulnerable individuals. Specifically, these structures explained why some participants were resilient to the deleterious effects of elevated brain amyloid and poor vascular health. Of these, medial temporal lobe and fornix, reflec

SUBMITTER: Saboo KV 

PROVIDER: S-EPMC9045384 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature