Dataset Information

Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFR^T790M tyrosine kinase inhibitors.

ABSTRACT: Fourteen recent thiazolidine-2,4-diones bearing furan and/or thiophene heterocyclic rings have been designed, synthesized and assessed for their anticancer activities against four human tumor cell lines HepG2, A549, MCF-7 and HCT-116 targeting both VEGFR-2 and EGFR tyrosine kinases. Molecular design was carried out to investigate the binding mode of the proposed compounds with VEGFR-2 and EGFR receptors. HepG2 was the most susceptible cell line to the influence of our derivatives. Compounds 5g and 4g revealed the highest activities against HepG2 (IC₅₀ = 3.86 and 6.22 μM), A549 (IC₅₀ = 7.55 and 12.92 μM), MCF-7 (IC₅₀ = 10.65 and 10.66 μM) and HCT116 (IC₅₀ = 9.04 and 11.17 μM) tumor cell lines. Sorafenib (IC₅₀ = 4.00, 4.04, 5.58 and 5.05

SUBMITTER: Aziz NAAM

PROVIDER: S-EPMC9045483 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFR^T790M tyrosine kinase inhibitors.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFRT790M tyrosine kinase inhibitors.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFR^T790M tyrosine kinase inhibitors.