Prize Presentations: ACHARI PRIZE
Ontology highlight
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PROVIDER: S-EPMC9045589 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Project description: Not available
| S-EPMC9045590 | biostudies-literature
Project description:The common histones H2A, H2B, H3, and H4 are the characteristic components of eukaryotic nucleosomes, which function to wrap DNA and compact the genome as well as to regulate access to DNA for transcription and replication in all eukaryotes. In the past two decades, histones have also been found to be encoded in some DNA viruses, where their functions and properties are largely unknown, though recently histones from two related viruses have been shown to form nucleosome-like structures in vitro. Viral histones can be highly similar to eukaryotic histones in primary sequence, suggesting they have been recently picked up from eukaryotic hosts, or they can be radically divergent in primary sequence and may occur as conjoined histone doublets, triplets, or quadruplets, suggesting ancient origins prior to the divergence of modern eukaryotes. Here, we review what is known of viral histones and discuss their possible origins and functions. We consider how the viral life cycle may affect their properties and histories, and reflect on the possible roles of viruses in the origin of the nucleus of modern eukaryotic cells.
| S-EPMC9145170 | biostudies-literature
Project description:This data article is an expression of data that reflects how students' participation in the Hult Prize 2018 regional finals affects their decision to become entrepreneurs. The primary data was sourced using a questionnaire developed with Google doc form. Out of 120 students that participated in the Hult Prize 2018 regional finals in Nigeria, 103 of them responded. Their responses are as presented in this article. Such will be relevant to researchers who want to find out why students desire to become entrepreneurs and the best approach and timing to enable them.
| S-EPMC5997922 | biostudies-literature
Project description:The 2018 Nobel Prize in Physiology or Medicine was awarded to Tasuku Honjo and James Allison for their discoveries in cancer immunology. Professor Honjo was awarded due to his discovery of the programmed death molecule-1 (PD-1) on T cells. Professor Allison discovered another important immunosuppressive molecule: cytotoxic T-lymphocyte antigen-4 (CTLA-4). Suppression of T cell activation by PD-1 and/or CTLA-4 is considered one of the major escape mechanisms of cancer cells. Inhibition of these molecules by immune checkpoint inhibitors can successfully activate the immune system to fight cancer. Checkpoint inhibitors have brought about a major breakthrough in cancer immunotherapy, reviving the hope of curing patients with end-stage cancer, including a wide variety of cancer types. In metastatic malignant melanoma, the previous long-term survival of only 5% can now be extended to 50% with anti-PD-1 plus anti-CTLA-4 combined treatment in the latest report. More checkpoint molecules such as lymphocyte-activation gene 3 and T cell immunoglobulin and mucin domain 3 are under investigation. The achievement of Drs. Honjo and Allison in cancer immunotherapy has encouraged research into other immune-pathological diseases.
| S-EPMC6889239 | biostudies-literature