A personalized and dynamic risk estimation model: The new paradigm in Barrett's esophagus surveillance.

ABSTRACT:

Objectives

The current surveillance strategy in Barrett's esophagus (BE) uses only histological findings of the last endoscopy to assess neoplastic progression risk. As predictor values vary across endoscopies, single measurements may not be an accurate reflection. Our aim was to explore the value of using longitudinal evolutions (i.e. successive measurements) of histological findings (low-grade dysplasia (LGD)) and immunohistochemical biomarkers (p53 and SOX2) by investigating the association with Barrett's progression.

Methods

In this proof-of-principle study of a longitudinal dynamic risk estimation model with a multicenter cohort design, 631 BE patients from 15 Dutch hospitals who were under surveillance were included. Longitudinal dynamic values of LGD, p53, and SOX2 we

SUBMITTER: Roumans CAM 

PROVIDER: S-EPMC9045660 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature