Ontology highlight
ABSTRACT:
SUBMITTER: Shaban NM
PROVIDER: S-EPMC9045721 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Shaban Nadine M NM Yan Rui R Shi Ke K Moraes Sofia N SN Cheng Adam Z AZ Carpenter Michael A MA McLellan Jason S JS Yu Zhiheng Z Harris Reuben S RS
Science advances 20220427 17
Viruses use a plethora of mechanisms to evade immune responses. A recent example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (EBV) ribonucleotide reductase subunit BORF2. Cryo-EM studies of APOBEC3B-BORF2 complexes reveal a large >1000-Å<sup>2</sup> binding surface composed of multiple structural elements from each protein, which effectively blocks the APOBEC3B active site from accessing single-stranded DNA substrates. Evolutionary optimization is s ...[more]