Environmental eustress improves postinfarction cardiac repair via enhancing cardiac macrophage survival.

ABSTRACT: Macrophages play a vital role in cardiac repair following myocardial infarction (MI). An enriched environment (EE) is involved in the regulation of macrophage-related activities and disease progression; however, whether EE affects the phenotype and function of macrophages to improve postinfarction cardiac repair remains unknown. In this study, we found that EE improved cardiac function, decreased mortality, and ameliorated adverse ventricular remodeling in mice after MI, with these outcomes closely related to the increased survival of Ly6C^low macrophages and their CCR2^-MHCII^low subsets. EE increased the expression of brain-derived neurotrophic factor (BDNF) in the hypothalamus, leading to higher circulating levels of BDNF, which, in turn, regulated the card

SUBMITTER: Bai PY 

PROVIDER: S-EPMC9045726 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature