Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells.

ABSTRACT: Influenza A virus still represents a noticeable epidemic risk to international public health at present, despite the extensive use of vaccines and anti-viral drugs. In the fight against pathogens, the immune defence lines consisting of diverse lymphocytes are indispensable for humans. However, the role of virus infection of lymphocytes and subsequent abnormal immune cell death remains to be explored. Different T cell subpopulations have distinct characterizations and functions, and we reveal the high heterogeneity of susceptibility to viral infection and biological responses such as apoptosis in various CD4⁺ T and CD8⁺ T cell subsets through single-cell transcriptome analyses. Effector memory CD8⁺ T cells (CD8⁺ T_EM) that mediate protec

SUBMITTER: Yu J 

PROVIDER: S-EPMC9045768 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature