Emerging Therapies for COVID-19: The Value of Information From More Clinical Trials.

ABSTRACT:

Objectives

The COVID-19 pandemic necessitates time-sensitive policy and implementation decisions regarding new therapies in the face of uncertainty. This study aimed to quantify consequences of approving therapies or pursuing further research: immediate approval, use only in research, approval with research (eg, emergency use authorization), or reject.

Methods

Using a cohort state-transition model for hospitalized patients with COVID-19, we estimated quality-adjusted life-years (QALYs) and costs associated with the following interventions: hydroxychloroquine, remdesivir, casirivimab-imdevimab, dexamethasone, baricitinib-remdesivir, tocilizumab, lopinavir-ritonavir, interferon beta-1a, and usual care. We used the model outcomes to conduct cost-effectiveness and value of infor

SUBMITTER: Dijk SW 

PROVIDER: S-EPMC9045876 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature