Catalytic synthesis of phenols with nitrous oxide.

ABSTRACT: The development of catalytic chemical processes that enable the revalorization of nitrous oxide (N₂O) is an attractive strategy to alleviate the environmental threat posed by its emissions^1-6. Traditionally, N₂O has been considered an inert molecule, intractable for organic chemists as an oxidant or O-atom transfer reagent, owing to the harsh conditions required for its activation (>150 °C, 50‒200 bar)^7-11. Here we report an insertion of N₂O into a Ni‒C bond under mild conditions (room temperature, 1.5-2 bar N₂O), thus delivering valuable phenols and releasing benign N₂. This fundamentally distinct organometallic C‒O bond-forming step differs from the current strategies based on reductive elimination and enables a

SUBMITTER: Le Vaillant F 

PROVIDER: S-EPMC9046086 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature