Superoxide dismutase 6 is required during metamorphosis for the development of properly movable legs in Tribolium castaneum.

ABSTRACT: The body form of holometabolous insects dramatically transforms from larval to adult stages during metamorphosis that occurs in the pupal stage. The larval disorganization and then new adult tissues are built up at this time. In motoneuron, larval neuronal cells degenerate, and new adult neurons are remodeled. Finally, adult neurons reconnect to new adult muscles. However, the factors that control metamorphosis have not yet been fully elucidated. Here, we show that an antioxidant enzyme, Tribolium castaneum superoxide dismutase 6 (TcSOD6), is secreted into the haemolymph and is required for proper movable legs during metamorphosis. TcSOD6 has a unique domain architecture and is mainly expressed in the pupal stage. The depletion of TcSOD6 expression in the pupa inhibits normal axon developm

SUBMITTER: Nishiko M 

PROVIDER: S-EPMC9046187 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature