Plasma homocysteine and macular thickness in older adults-the Rugao Longevity and Aging Study.

ABSTRACT:

Objectives

To determine the association of plasma homocysteine levels with retinal layer thickness in a large community cohort of older adults.

Methods

The Rugao Longevity and Ageing Study is an observational, prospective and community-based cohort study. A total of 989 older adults who underwent spectral-domain optical coherence tomography (SD-OCT) were included and analyzed. Foveal, macular retinal nerve fibre layer (mRNFL) and ganglion cell layer plus inner plexiform layer (GC-IPL) thicknesses were measured by SD-OCT. Plasma homocysteine levels were measured using chemiluminescence immunoassay. Linear regression analyses were performed to evaluate the relationship between plasma homocysteine and retinal layer thickness while controlling for confounding factors.

Results

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9046221 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature