Association of central serous chorioretinopathy with single nucleotide polymorphisms in complement factor H gene in Iranian population.

ABSTRACT:

Objectives

To investigate the association of two different single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene with central serous chorioretinopathy (CSCR) in the Iranian population.

Methods

This is a case-control study with 95 participants in each group who were stratified according to their various ethnical variations. Primers for rs1329428 and rs3753394 polymorphisms were synthesized. DNA was extracted from peripheral blood leukocytes and underwent PCR and high-resolution melt analysis.

Results

The frequency of tt, ct, and cc genotypes for rs1329428 polymorphism was 22 (26.5%), 46 (55.4%), and 15 (18.1%) in acute CSCR and 5 (41.7%), 5 (41.7%), and 2 (16.7%) in chronic CSCR respectively with no significant difference between case and control

SUBMITTER: Karkhaneh R 

PROVIDER: S-EPMC9046259 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature