High altitude is associated with pTau deposition, neuroinflammation, and myelin loss.

ABSTRACT: Mammals are able to adapt to high altitude (HA) if appropriate acclimation occurs. However, specific occupations (professional climbers, pilots, astronauts and other) can be exposed to HA without acclimation and be at a higher risk of brain consequences. In particular, US Air Force U2-pilots have been shown to develop white matter hyperintensities (WMH) on MRI. Whether WMH are due to hypoxia or hypobaria effects is not understood. We compared swine brains exposed to 5000 feet (1524 m) above sea level (SL) with 21% fraction inspired O₂ (FiO₂) (Control group [C]; n = 5) vs. 30,000 feet (9144 m) above SL with 100% FiO₂ group (hypobaric group [HYPOBAR]; n = 6). We performed neuropathologic assessments, molecular analyses, immunohistochemistry (IHC), Western Blo

SUBMITTER: Iacono D 

PROVIDER: S-EPMC9046305 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature