Multicenter, prospective, observational study of chemotherapy-induced dysgeusia in gastrointestinal cancer.

ABSTRACT:

Purpose

Dysgeusia is an adverse event caused by chemotherapy. Although retrospective studies have shown zinc administration improves dysgeusia, there have been no prospective studies. The present study examined effects of zinc therapy on dysgeusia in patients with gastrointestinal cancer.

Methods

This multicenter, prospective, observational study enrolled patients with dysgeusia during chemotherapy treatment. Patients received no intervention (control), polaprezinc p.o., or zinc acetate hydrate p.o., and serum zinc levels were measured at 0 (baseline), 6, and 12 weeks. Dysgeusia was assessed using CTCAE v5.0 and subjective total taste acuity (STTA) criteria using questionnaires at baseline and 12 weeks.

Results

From February 2020 to June 2021, 180 patients were enroll

SUBMITTER: Ito K 

PROVIDER: S-EPMC9046346 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature