Evaluation of outer nuclear layer overshadowed by retinal vessels in retinitis pigmentosa.

ABSTRACT:

Objectives

We investigated in vivo light-induced photoreceptor damage in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) images.

Methods

We retrospectively reviewed patients with genetic diagnosis of EYS-associated RP. The outer nuclear layer (ONL) thickness under retinal vessels was measured on SD-OCT vertical scans. As a control, we measured adjacent ONL thickness 100 μm superior and inferior from the vessel. Same measurements were performed in healthy subjects. We calculated the ratio of ONL thickness under vessel divided by the average of adjacent ONL thickness and defined as ONL preservation ratio. In patients with RP, the length of ellipsoid zone (EZ) from the fovea was also measured with SD-OCT vertical scans.

Results

Thirt

SUBMITTER: Otsuka Y 

PROVIDER: S-EPMC9046433 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature