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Peptide hydrogel with self-healing and redox-responsive properties.

ABSTRACT: We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.

SUBMITTER: D'Souza A

PROVIDER: S-EPMC9046503 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Peptide hydrogel with self-healing and redox-responsive properties.

D'Souza Areetha A Marshall Liam R LR Yoon Jennifer J Kulesha Alona A Edirisinghe Dona I U DIU Chandrasekaran Siddarth S Rathee Parth P Prabhakar Rajeev R Makhlynets Olga V OV

Nano convergence 20220427 1

We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ...[more]

PMID: 35478076

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Project description:The development of conductive hydrogels has garnered significant attention in the field of wearable devices and smart sensors. However, the fabrication of hydrogels that possess both multifunctionality and structural stability remains a challenging task. In this study, a novel hydrogel, PAgHCB, was synthesized using a mild method and exhibited outstanding characteristics such as electrical conductivity, self-healing capability, antimicrobial activity, dimensional stability, and temperature sensitivity. The exceptional mechanical performance (∼120 kPa at a strain of 450%) of PAgHCB is attributed to the incorporation of hydroxypropylmethylcellulose (HPMC) and the mechanical reinforcement of the gel network by carboxylated carbon nanotubes (CNT-COOH). The borate bonds between or within poly(vinyl alcohol) (PVA) chains confer self-healing capabilities upon PAgHCB, with a healing efficiency of 74.1%. The in situ reduction of silver nanoparticles through ultraviolet irradiation imparts antimicrobial characteristics to the hydrogel [against Escherichia coli, zone of inhibition (ZOI) = 3.7 mm; against Staphylococcus aureus, ZOI = 6.3 mm]. The linear temperature responsiveness of the PAgHCB hydrogel (R = -3.99T + 608.84 and COD = 0.9988) arises from the migration of silver ions within the gel matrix and the dissociation of borate bonds. Furthermore, PAgHCB was seamlessly integrated into sensors designed for monitoring human motion. The gel-based sensors exhibited three distinct sensing strain ranges corresponding to three different gauge factors (GF1 = 2.976, GF2 = 1.063, and GF3 = 2.97). Notably, PAgHCB gel sensors demonstrated the capability to detect electrical signals generated by finger and wrist joint movements and even discerned signals arising from subtle deformations induced by activities such as speaking. Additionally, the PAgHCB gel was utilized as a pressure sensor to detect external pressures applied to the skin (from 0.373 to 15.776 kPa). This work expands the avenues for designing and synthesizing multifunctional conductive hydrogels, promoting the application of hydrogel sensors with comfortable wear and high sensitivity.

Dataset Information

Peptide hydrogel with self-healing and redox-responsive properties.

Publications

Peptide hydrogel with self-healing and redox-responsive properties.

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