Gene Mutations Associated With Clinical Characteristics in the Tumors of Patients With Breast Cancer.

ABSTRACT:

Background

Clinical characteristics including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) are important biomarkers in the treatment of breast cancer, but how genomic mutations affect their status is rarely studied. This study aimed at finding genomic mutations associated with these clinical characteristics.

Methods

There were 160 patients with breast cancer enrolled in this study. Samples from those patients were used for next-generation sequencing, targeting a panel of 624 pan-cancer genes. Short nucleotide mutations, copy number variations, and gene fusions were identified for each sample. Fisher's exact test compared each pair of genes. A similarity score was constructed with the resulting P-values. Genes were clus

SUBMITTER: Hao C 

PROVIDER: S-EPMC9046571 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature