Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8⁺ T Cells in Local Tumor Microenvironment.

ABSTRACT: In the tumor microenvironment (TME), the activation of programmed death-1 (PD-1)-programmed death ligand-1 (PD-L1) pathway is one of the main signals of immune escape and tumor deterioration. Clinically, the application of monoclonal antibodies slows down the progression of various malignancies and prolongs the survival of patients effectively. However, these treatments result in serious immune-related adverse events (irAEs) owning to systemic immune activation. Therefore, to achieve long-term therapeutic effects and low side effects, it is necessary to find drugs inhibiting the local PD-1/PD-L1 signaling pathway of the TME. Here, we discovered that Platycodon grandiflorum (PG), a medicine and food homology herb, reduced the expression of PD-1 on the surface of CD8⁺ T cel

SUBMITTER: Yang R 

PROVIDER: S-EPMC9046572 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature