Immune Gene Signatures and Immunotypes in Immune Microenvironment Are Associated With Glioma Prognose.

ABSTRACT: Glioma is the most common primary malignant brain tumor in adults with very poor prognosis. The limited new therapeutic strategies for glioma patients can be partially attributed to the complex tumor microenvironment. However, knowledge about the glioma immune microenvironment and the associated regulatory mechanisms is still lacking. In this study, we found that, different immune subtypes have a significant impact on patient survival. Glioma patients with a high immune response subtype had a shorter survival compared with patients with a low immune response subtype. Moreover, the number of B cell, T cell, NK cell, and in particular, the macrophage in the immune microenvironment of patients with a high immune response subtype were significantly enhanced. In addition, 132 genes were found t

SUBMITTER: Wang XX 

PROVIDER: S-EPMC9046586 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature