Safety, Immunogenicity, and Efficacy of COVID-19 Vaccines in Adolescents, Children, and Infants: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

As the epidemic progresses, universal vaccination against COVID-19 has been the trend, but there are still some doubts about the efficacy and safety of COVID-19 vaccines in adolescents, children, and even infants.

Purpose

To evaluate the safety, immunogenicity, and efficacy of COVID-19 vaccines in the population aged 0-17 years.

Method

A comprehensive search for relevant randomized controlled trials (RCTs) was conducted in PubMed, Embase, and the Cochrane Library from inception to November 9, 2021. All data were pooled by RevMan 5.3 statistical software, with risk ratio (RR) and its 95% confidence interval as the effect measure. This study protocol was registered on PROSPERO (CRD42021290205).

Results

There was a total of six randomized controlled tri

SUBMITTER: Du Y 

PROVIDER: S-EPMC9046659 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature