Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes.

ABSTRACT:

Background

Genetic studies have linked polymorphisms in the interleukin 6 receptor (IL6R) gene to the risk of multiple human diseases and phenotypes, yet have reported inconsistent results. We aimed to synthesize current knowledge of variants in the IL6R gene on the risk of diseases and phenotypes.

Methods

We searched the Medline and Embase databases to identify relevant publications. Meta-analysis was performed utilizing DerSimonian and Laird random-effects model. We also graded cumulative evidence for significant associations. Furthermore, phenome-wide analyses and functional annotations were performed for variants with strong evidence.

Results

We included 155 studies for evaluating the associations between 80 polymorphisms in the IL6R gene and

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9046675 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature