The Polymorphism and Expression of EGFL7 and miR-126 Are Associated With NSCLC Susceptibility.

ABSTRACT: Previous investigations have reported that microRNA-126 (miR-126) and its host gene, epidermal growth factor-like domain-containing protein 7 (EGFL7) are involved in lung cancer progression, suggesting EGFL7 and miR-126 play a joint role in lung cancer development. In this study, we analyzed the methylation-associated regulation of EGFL7 and miR-126 in non-small cell lung cancer (NSCLC) and further investigated the association between EGFL7/miR-126 polymorphisms and NSCLC susceptibility in the Han Chinese population. Based on our data, relative to those in adjacent normal tissue, both EGFL7 expression and miR-126 expression were decreased significantly in lung cancer tissue (P = 3x10^-4 and P < 1x10^-4), and the expression of EGFL7 mRNA and miR-126 was sig

SUBMITTER: Liu W 

PROVIDER: S-EPMC9046731 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature