Study Protocol: A Randomized Controlled Prospective Single-Center Feasibility Study of Rheopheresis for Raynaud's Syndrome and Digital Ulcers in Systemic Sclerosis (RHEACT Study).

ABSTRACT:

Introduction

Raynaud's phenomenon (RP) and digital ulcers (DU) are frequent manifestations of Systemic Sclerosis (SSc). Despite being very common in SSc patients, both conditions have proven to be notoriously difficult to study. There are very few available approved drugs with varying efficacy. It has been shown that the presence of DU is associated with increased whole blood viscosity (WBV). Rheopheresis (RheoP) is an extracorporeal apheresis technique used to treat microcirculatory disorders by improving blood viscosity. Improved blood flow and wound healing after RheoP treatments have been reported in single case reports.

Methods and analysis

We report the clinical trial protocol of "A randomized controlled prospective single-center feasibility study of Rheopheresis fo

SUBMITTER: Rademacher JG 

PROVIDER: S-EPMC9046781 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature