White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder.

ABSTRACT:

Background

The efficacy and prognosis of major depressive disorder (MDD) are limited by its heterogeneity. MDD with melancholic features is an important subtype of MDD. The present study aimed to reveal the white matter (WM) network changes in melancholic depression.

Materials and methods

Twenty-three first-onset, untreated melancholic MDD, 59 non-melancholic MDD patients and 63 health controls underwent diffusion tensor imaging (DTI) scans. WM network analysis based on graph theory and support vector machine (SVM) were used for image data analysis.

Results

Compared with HC, small-worldness was reduced and abnormal node attributes were in the right orbital inferior frontal gyrus, left orbital superior frontal gyrus, right caudate nucleus, right orbital superior fronta

SUBMITTER: He M 

PROVIDER: S-EPMC9046786 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature