MC4R Gene Polymorphisms Interact With the Urbanized Living Environment on Obesity: Results From the Yi Migrant Study.

ABSTRACT: Objectives: This study aimed to determine the association of MC4R gene polymorphisms (rs17782313 and rs12970134) and urbanized living environment and the gene-environment interaction with obesity in Yi people in China. Methods: A 1:2 frequency-matched case-control study based on the cross-sectional data was designed. Those with BMI ≥28 kg/m² were included as the case group. The age- and sex-matched controls were selected from those with BMI <24 kg/m². Unconditional logistic models were used to determine the association of SNPs with obesity. Additive interaction was evaluated by calculating relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI). Results: A total of 322 cases an

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9046839 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature