Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion.

ABSTRACT:

Objectives

Glucagon secretion to stimulate hepatic glucose production is the first line of defense against hypoglycemia. This response is triggered by so far incompletely characterized central hypoglycemia-sensing mechanisms, which control autonomous nervous activity and hormone secretion. The objective of this study was to identify novel hypothalamic genes controlling insulin-induced glucagon secretion.

Methods

To obtain new information on the mechanisms of hypothalamic hypoglycemia sensing, we combined genetic and transcriptomic analysis of glucagon response to insulin-induced hypoglycemia in a panel of BXD recombinant inbred mice.

Results

We identified two QTLs on chromosome 8 and chromosome 15. We further investigated the role of Irak4 and Cpne8, both located in t

SUBMITTER: Picard A 

PROVIDER: S-EPMC9046887 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature