Polypills for Primary Prevention of Cardiovascular Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Purpose

To evaluate the effect of polypills on the primary prevention of cardiovascular (CV) events using data from clinical trials.

Methods

We searched PubMed, Web of Science, EBSCO, and SCOPUS throughout May 2021. Two authors independently screened articles for the fulfillment of inclusion criteria. The RevMan software (version 5.4) was used to calculate the pooled risk ratios (RRs) and mean differences (MDs), along with their associated confidence intervals (95% CI).

Results

Eight trials with a total of 20653 patients were included. There was a significant reduction in the total number of fatal and non-fatal CV events among the polypill group [RR (95% CI) = 0.71 (0.63, 0.80); P-value < 0.001]. This reduction was observed in both the intermediate-risk [RR (95

SUBMITTER: Kandil OA 

PROVIDER: S-EPMC9046936 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature