Differences in hippocampal plasticity and memory outcomes in anterior versus posterior cerebellar stroke.

ABSTRACT: Neurological symptoms following cerebellar stroke can range from motor to cognitive-affective impairments. Topographic imaging studies from patients with lesions confined to the cerebellum have shown evidence linking anterior cerebellar lobules with motor function and posterior lobules with cognitive function. Damage to the cerebellum can disrupt functional connectivity in cerebellar stroke patients, as it is highly interconnected with forebrain motor and cognitive areas. The hippocampus plays a key role in memory acquisition, a cognitive domain that is negatively impacted by posterior cerebellar stroke, and there is increasing evidence that the cerebellum can affect hippocampal function in health and disease. To study these topographical dissociations, we developed a mouse photo-thrombosi

SUBMITTER: Moreno M 

PROVIDER: S-EPMC9047011 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature