Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth.

ABSTRACT:

Background

Preterm birth is defined as live birth before 37 completed weeks of pregnancy, and it is a major problem worldwide. The molecular mechanisms that lead to onset of spontaneous preterm birth are incompletely understood. Prediction and evaluation of the risk of preterm birth is challenging as there is a lack of accurate biomarkers. In this study, our aim was to identify placental proteins that associate with spontaneous preterm birth.

Methods

We analyzed the proteomes from placentas to identify proteins that associate with both gestational age and spontaneous labor. Next, rare and potentially damaging gene variants of the identified protein candidates were sought for from our whole exome sequencing data. Further experiments we performed on placental samples and place

SUBMITTER: Tiensuu H 

PROVIDER: S-EPMC9047282 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature