Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank.

ABSTRACT:

Background

Chronic kidney disease has been linked to worse cognition. However, this association may be dependent on the marker of kidney function used, and studies assessing modification by genetics are lacking. This study examined associations between multiple measures of kidney function and assessed effect modification by a polygenic score for general cognitive function.

Methods

In this cross-sectional study of up to 341,208 European ancestry participants from the UK Biobank study, we examined associations between albuminuria and estimated glomerular filtration rate based on creatinine (eGFRcre) or cystatin C (eGFRcys) with cognitive performance on tests of verbal-numeric reasoning, reaction time and visual memory. Adjustment for confounding factors was performed using mul

SUBMITTER: Richard EL 

PROVIDER: S-EPMC9047316 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature