Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development.

ABSTRACT:

Background

After embryonic development, Caenorhabditis elegans progress through for larval stages, each of them finishing with molting. The repetitive nature of C. elegans postembryonic development is considered an oscillatory process, a concept that has gained traction from regulation by a circadian clock gene homologue. Nevertheless, each larval stage has a defined duration and entails specific events. Since the overall duration of development is controlled by numerous factors, we have asked whether different rate-limiting interventions impact all stages equally.

Results

We have measured the duration of each stage of development for over 2500 larvae, under varied environmental conditions known to alter overall developmental rate. We applied changes in temperature and in th

SUBMITTER: Mata-Cabana A 

PROVIDER: S-EPMC9047341 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature