Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records.

ABSTRACT:

Background

Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental outcomes have been reported in humans. Bulls used for artificial insemination represent a relevant model in this field, as the broad dissemination of bull semen considerably alleviates confounding factors and enables the precise assessment of male fertility. This study was therefore designed to assess the potential for sperm DNA methylation to predict bull fertility.

Results

A unique collection of 100 sperm samples was constituted by pooling 2-5 ejaculates per bull from 100 Montbéliarde bulls of comparable ages, assessed as fertile (n = 57) or subfertile (n = 43) based on non-return rates 56 days after insemination. The DN

SUBMITTER: Costes V 

PROVIDER: S-EPMC9047354 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature