Tumor molecular differences associated with outcome disparities of Black patients with head and neck cancer.

ABSTRACT:

Background

Numerous studies of head and neck squamous cell carcinoma (HNSCC) have demonstrated disparate outcomes by race and ethnicity. Beyond known associations with socioeconomic variables, whether these are also associated with differences in tumor molecular composition has thus far been poorly explored.

Methods

We downloaded clinical and multiplatform molecular data from The Cancer Genome Atlas and other published studies. These were compared between non-Hispanic Black (n = 43) and White (n = 354) patients with non-HPV-related tumors, using multivariable models. Publicly available validation cohorts were used.

Results

Black patients had poorer progression-free survival than White patients. Tumors of Black patients had greater copy number aberrations, and increase

SUBMITTER: Kim HAJ 

PROVIDER: S-EPMC9047510 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature