Silent hypoxia is not an identifiable characteristic in patients with COVID-19 infection.

ABSTRACT:

Background

We aimed to assess whether asymptomatic ("happy") hypoxia was an identifiable physiological phenotype of COVID-19 acute respiratory distress syndrome (ARDS), and associated with need for ICU admission.

Methods

We performed an observational cohort study of all adult patients admitted with hypoxaemic respiratory failure to a large acute hospital Trust serving the East Midlands, UK. Patients with confirmed COVID-19 were compared to those without. Physiological response to hypoxaemia was modelled using a linear mixed effects model.

Results

Of 1,586 patients included, 75% tested positive for SARS-CoV-2. The ROX index was 2.08 min^-1 lower (1.56-2.61, p < 0.001) in the COVID-19 cohort when adjusted for age and ethnicity, suggesting an enhanced respirato

SUBMITTER: Plummer NR 

PROVIDER: S-EPMC9047547 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature