Circulating microRNA profiling is altered in the acute respiratory distress syndrome related to SARS-CoV-2 infection.

ABSTRACT: One of the hallmarks of SARS-CoV-2 infection is an induced immune dysregulation, in some cases resulting in cytokine storm syndrome and acute respiratory distress syndrome (ARDS). Several physiological parameters are altered as a result of infection and cytokine storm. Among them, microRNAs (miRNAs) might reflect this poor condition since they play a significant role in immune cellular performance including inflammatory responses. Circulating miRNAs in patients who underwent ARDS and needed mechanical ventilation (MV+; n = 15) were analyzed by next generation sequencing in comparison with patients who had COVID-19 poor symptoms but without intensive care unit requirement (MV-; n = 13). A comprehensive in silico analysis by integration with public gene expression dataset and pathway enrichm

SUBMITTER: Garcia-Giralt N 

PROVIDER: S-EPMC9047579 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature