Pushing the Limits on the Intestinal Crossing of Metal-Organic Frameworks: An Ex Vivo and In Vivo Detailed Study.

ABSTRACT: Biocompatible nanoscaled metal-organic frameworks (nanoMOFs) have been widely studied as drug delivery systems (DDSs), through different administration routes, with rare examples in the convenient and commonly used oral administration. So far, the main objective of nanoMOFs as oral DDSs was to increase the bioavailability of the cargo, without considering the MOF intestinal crossing with potential advantages (e.g., increasing drug availability, direct transport to systemic circulation). Thus, we propose to address the direct quantification and visualization of MOFs' intestinal bypass. For that purpose, we select the microporous Fe-based nanoMOF, MIL-127, exhibiting interesting properties as a nanocarrier (great biocompatibility, large porosity accessible to different drugs, green and multi

SUBMITTER: Rojas S 

PROVIDER: S-EPMC9047668 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature