Hybrid Theranostic Cubosomes for Efficient NIR-Induced Photodynamic Therapy.

ABSTRACT: In recent years, lipid bicontinuous cubic liquid-crystalline nanoparticles known as cubosomes have been under investigation because of their favorable properties as drug nanocarriers useful for anticancer treatments. Herein, we present organic/inorganic hybrid, theranostic cubosomes stabilized in water with a shell of alternate layers of chitosan, single strand DNA (model genetic material for potential gene therapy), and folic acid-chitosan conjugate (the outmost layer), coencapsulating up-converting Er³⁺ and Yb³⁺ codoped NaYF₄ nanoparticles and daunorubicin. The latter acts as a chemotherapeutic drug of photosensitizing activity, while up-converting nanoparticles serve as energy harvester and diagnostic agent. Cellular uptake and NIR-induced photodynamic t

SUBMITTER: Bazylinska U 

PROVIDER: S-EPMC9047672 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature