Low tidal volume ventilation is associated with mortality in COVID-19 patients-Insights from the PRoVENT-COVID study.

ABSTRACT:

Purpose

Low tidal volume ventilation (LTVV) is associated with mortality in patients with acute respiratory distress syndrome. We investigated the association of LTVV with mortality in COVID-19 patients.

Methods

Secondary analysis of a national observational study in COVID-19 patients in the first wave of the pandemic. We compared COVID-19 patients that received LTVV, defined as controlled ventilation with a median tidal volume ≤ 6 mL/kg predicted body weight over the first 4 calendar days of ventilation, with patients that did not receive LTVV. The primary endpoint was 28-day mortality. In addition, we identified factors associated with use of LTVV.

Results

Of 903 patients, 294 (32.5%) received LTVV. Disease severity scores and ARDS classification was not different b

SUBMITTER: Nijbroek SGLH 

PROVIDER: S-EPMC9047696 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature