Risk of Invasive Cutaneous Squamous Cell Carcinoma After Different Treatments for Actinic Keratosis: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

Treatment of actinic keratosis (AK) aims to prevent cutaneous squamous cell carcinoma (cSCC). However, whether AK can progress into invasive cSCC is a matter of debate, and little is known about the effect of treatment on preventing cSCC.

Objectives

To evaluate the risk of invasive cSCC and factors that may contribute to increased risk in patients with multiple AKs.

Design, setting, and participants

In this secondary analysis of a multicenter randomized clinical trial, 624 patients with a minimum of 5 AKs within an area of 25 to 100 cm2 on the head were recruited from the Department of Dermatology of 4 hospitals in the Netherlands. Long-term follow-up was performed from July 1, 2019, to December 31, 2020.

Interventions

Patients were randomized to tre

SUBMITTER: Ahmady S 

PROVIDER: S-EPMC9047727 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature