Cortical Thickness Abnormalities at Different Stages of the Illness Course in Schizophrenia: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Questions of whether and how cortical thickness (CTh) alterations differ over the course of schizophrenia (SCZ) have yet to be resolved.

Objective

To characterize CTh alterations across illness stages in SCZ.

Data sources

PubMed, Embase, Web of Science, and Science Direct were screened for CTh studies published before June 15, 2021.

Study selection

Original studies comparing whole-brain CTh alterations from healthy controls in individuals at clinical high-risk (CHR), first episode of psychosis (FEP), and long-term illness stages of SCZ were included.

Data extraction and synthesis

This preregistered systematic review and meta-analysis followed PRISMA reporting guidelines. Separate and pooled meta-analyses were performed using seed-based d mappi

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9047772 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature