The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population.

ABSTRACT:

Background

Pharmacogenomics (PGx), forming the basis of precision medicine, has revolutionized traditional medical practice. Currently, drug responses such as drug efficacy, drug dosage, and drug adverse reactions can be anticipated based on the genetic makeup of the patients. The pharmacogenomic data of Pakistani populations are limited. This study investigates the frequencies of pharmacogenetic variants and their clinical relevance among ethnic groups in Pakistan.

Methods

The Pharmacogenomics Knowledge Base (PharmGKB) database was used to extract pharmacogenetic variants that are involved in medical conditions with high (1A + 1B) to moderate (2A + 2B) clinical evidence. Subsequently, the allele frequencies of these variants were searched among multiethnic groups of Pakista

SUBMITTER: Khan AR 

PROVIDER: S-EPMC9047794 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature