NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities.

ABSTRACT:

Background

Thiopurines are widely used as anti-cancer and immunosuppressant agents, but have a narrow therapeutic index owing to frequent toxicity and life-threatening bone marrow suppression. The nudix hydrolase 15 (NUDT15) genetic polymorphism is strongly associated with the tolerance and myelosuppressive effect of mercaptopurine administration, but the frequency of NUDT15 variants is known to vary among different ethnic groups or nationalities. At present, the NUDT15 gene polymorphism in ethnic minorities such as the Uighur, Kirghiz, and Dai nationalities in China is unclear.

Procedure

DNA samples were isolated from 1,071 Chinese children, including 675 Han children with acute lymphoblastic leukemia and 396 healthy minority children, including

SUBMITTER: Zhang F 

PROVIDER: S-EPMC9047856 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature