Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals.

ABSTRACT: Metformin and statins are currently the focus of large clinical trials testing their ability to counter age-associated declines in health, but recent reports suggest that both may negatively affect skeletal muscle response to exercise. However, it has also been suggested that metformin may act as a possible protectant of statin-related muscle symptoms. The potential impact of combined drug use on the hypertrophic response to resistance exercise in healthy older adults has not been described. We present secondary statin analyses of data from the MASTERS trial where metformin blunted the hypertrophy response in healthy participants (>65 years) following 14 weeks of progressive resistance training (PRT) when compared to identical placebo treatment (n = 94). Approximately one-third of M

SUBMITTER: Long DE 

PROVIDER: S-EPMC9047873 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature