Associations of Serum Serotonin Levels with 12-week and 12-month Remission in Patients with Depressive Disorders.

ABSTRACT:

Objective

To investigate associations between baseline serum serotonin levels and short- and long-term treatment outcomes in outpatients with depressive disorders in a naturalistic one-year prospective study design.

Methods

Patients were recruited at a University hospital in South Korea from March 2012 to April 2017. At baseline, blood samples were obtained from 1,094 patients who received initial antidepressant monotherapy (Step 1). After the Step 1 treatment, further treatment steps (at least Steps 2-4) could be administered every 3 weeks during the acute treatment phase (3, 6, 9, and 12 weeks; n = 1,086), and every 3 months during the continuation treatment phase (6, 9, and 12 months; n = 884). In cases showing an insufficient response or intolerable side effects, patient

SUBMITTER: Choi W 

PROVIDER: S-EPMC9048016 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature